The Laboratory, headed by Dr. Kevin Corbett, is focused on the molecular mechanisms of chromosome segregation in meiosis. We are most interested in understanding the organizational principles of meiotic chromosomes and their protein scaffolds, the regulation of meiotic DNA breakage and recombination to create crossovers, and the checkpoint mechanisms that monitor crossover formation to ensure high-fidelity chromosome segregation in meiosis I. The group uses biochemistry, X-ray crystallography, and genetics in S. cerevisiae to address these questions.

Structural Biology